Decreased susceptibility to polymyxins emerging during treatment for carbapenem-resistant Enterobacter aerogenes infection
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چکیده
منابع مشابه
Decreased susceptibility to polymyxin B during treatment for carbapenem-resistant Klebsiella pneumoniae infection.
In the United States, the major mechanism of carbapenem resistance among Enterobacteriaceae is the production of Klebsiella pneumoniae carbapenemase (KPC) (2). Polymyxins and tigecycline are the antimicrobials most often used for treatment of infections caused by carbapenem-resistant Enterobacteriaceae (4, 11). Polymyxin B, discovered more than 60 years ago, has been reintroduced as a valuable ...
متن کاملAmpicillin/sulbactam compared with polymyxins for the treatment of infections caused by carbapenem-resistant Acinetobacter spp.
BACKGROUND There has been an increase in worldwide infections caused by carbapenem-resistant Acinetobacter. This poses a therapeutic challenge as few treatment options are available. OBJECTIVES The aim of this study was to evaluate the efficacy and safety of polymyxins and ampicillin/sulbactam for treating infections caused by carbapenem-resistant Acinetobacter spp. and to evaluate prognostic...
متن کاملCarbapenem resistance in a clinical isolate of Enterobacter aerogenes is associated with decreased expression of OmpF and OmpC porin analogs.
We investigated the mechanism of imipenem resistance in Enterobacter aerogenes strain 810, a clinical isolate from the United States for which the imipenem MIC was 16 micro g/ml and the meropenem MIC was 8 micro g/ml. An imipenem-susceptible revertant, strain 810-REV, was obtained after multiple passages of the strain on nonselective media. For the revertant, the imipenem MIC was </=1 micro g/m...
متن کاملINFECTIOUS DISEASES Brief communication KPC-producing Enterobacter aerogenes infection
Background: Enterobacter is a common nosocomial microorganism and its carbapenem’s resistance has increased. The management of these cases is unclear. Objective: We evaluated 16 patients with KPC-producing Enterobacter aerogenes infections, detailing the site of infection, therapy, clinical and epidemiological data. Methods: A retrospective and descriptive study. Clinical data were revised and ...
متن کاملEmergence of the Plasmid-Mediated mcr-1 Gene in Colistin-Resistant Enterobacter aerogenes and Enterobacter cloacae.
Kun-jiao Zeng, Yohei Doi, Sandip Patil, Xi Huang, Guo-Bao Tian Program of Immunology, Institute of Human Virology, Institute of Tuberculosis Control, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China; Key Laboratory of Tropical Diseases Control (Sun Yat-sen University), Ministry of Education, Guangzhou, China; Division of Infectious Diseases, University of Pittsburgh Medica...
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ژورنال
عنوان ژورنال: International Journal of Infectious Diseases
سال: 2010
ISSN: 1201-9712
DOI: 10.1016/j.ijid.2010.02.1581